Aspinwall is a surname. Notable people with the surname include:
Edward Aspinwall (died 1732), English priest
Homer F. Aspinwall (1846–1919), American politician
Lloyd Aspinwall (1834–1886), American New York National Guard general
Nan Aspinwall (1880–1964), American equestrian who performed under the moniker "Two-Gun Nan"; first woman to cross the United States on horseback.
William Aspinwall (1605–1662), Englishman emigrant to Boston
William Henry Aspinwall (1807–1875), Founder of the Pacific Mail Steamship Company and the Panama Railroad, partner in Howland & Aspinwall
