Suvarna Garge (Editor)

Arrestin beta 2

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Covid-19
Species  Human
Entrez  409
Human  Mouse
Ensembl  ENSG00000141480
Arrestin beta 2
Aliases  ARRB2, ARB2, ARR2, BARR2, Arrestin beta 2
External IDs  MGI: 99474 HomoloGene: 3183 GeneCards: ARRB2

Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals, as well as having signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

The protein may interact with the agonist DOI in 5-HT2A receptor signaling.

Interactions

Arrestin beta 2 has been shown to interact with

  • AP2B1,
  • PSCD2,
  • Mdm2, and
  • RALGDS.
  • References

    Arrestin beta 2 Wikipedia


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