Arana or Araña is a surname. Notable people with the surname include:
Diego de Arana (1468–1493), Castillan sailor
Agustín Sauto Arana (1908–1986), Basque footballer
Alfonso Arana (1927–2005), Puerto Rican painter
Diego Barros Arana (1830–1907), Chilean historian
Facundo Arana (born 1972), Argentinian actor
Fernando Ortíz Arana (born 1944), Mexican politician
Francisco Javier Arana (1905–1949), Guatemalan military leader
Julio César Arana (1894–1952), Peruvian entrepreneur and politician
Mariano Arana (born 1933), Uruguayan architect and politician
Sabino Arana (1865–1903), founder of political Basque nationalism
Luis Arana Goiri (1862–1951), Basque Nationalist Party leader after Sabino Arana's death
Marie Arana, Peruvian-American writer, novelist, literary critic
Tomas Arana (born 1955), American actor
Vladimir Arana, Peruvian architect
Ryan Araña, Filipino basketball player
