Appleton is an Anglo-Saxon locational surname.
Alistair Appleton, British television presenterCharles Appleton (academic) (1841–1879), Oxford don and scholarly entrepreneurCharles Appleton (cricketer) (1844–1925), English amateur cricketerCharles William Appleton (1874–1945), vice president of the General Electric Company, judge and Assistant District Attorney in New York CityColin Appleton, footballerDaniel Appleton, American publisher, 1800s founder of D. Appleton & CompanyEdward Victor Appleton, English physicist, known for his research on the ionosphereEdwin Nelson Appleton, American Medal of Honor recipientGeorge Swett Appleton (1821–1878), American publisherHenry Appleton (fl. 1650–1654), English captain in the navy and commodoreJames Appleton (1786-1862), American abolitionistJohn Appleton, American diplomat, politician, and newspaper editorJohn Appleton (academic), Master of University College, Oxford, England (c.1401–8)John E. C. Appleton (1905–1990), Australian theatre and radio producerJohn F. Appleton (1838–1870), American Civil War general from MaineJohn Howard Appleton, American chemistJohn James Appleton (1789–1864), diplomat for the United StatesJon Appleton, American composer, author and professor of musicLarry Appleton, a character from the TV series Perfect StrangersMichael Appleton, footballerNatalie Appleton, British/Canadian singerNathan Appleton, American merchant and politicianNicole Appleton, British/Canadian singerRay Appleton (1941–2015), American jazz drummerRuel Ross Appleton (1853–1928), campaign manager for Mayor Gaynor of New York CitySamuel Appleton (1766–1853), an American merchant and philanthropistScott Appleton (1942-1992), American football playerThomas Gold Appleton (1812–1884), American author and artistVictor Appleton, a house pseudonym, famous for the Tom Swift seriesWilliam Appleton (politician) (1786–1862), congressman from MassachusettsWill Appleton (1889–1958), mayor of Wellington, New ZealandWilliam Sumner Appleton (1874–1947), founder of the Society for the Preservation of New England AntiquitiesWilliam M. Appleton (1920–2001), Pennsylvania politicianWilliam Henry Appleton (1814–1899), American publisherWilliam Appleton (entrepreneur) (born 1961), American entrepreneur and technologistWilliam H. Appleton (1843–1912), American soldier and Medal of Honor recipientWilliam Thomas Appleton (1859–1930), Australian businessman, shipping agent and public servant