Applegate is an English surname. Notable people with the surname include:
Andrew J. Applegate (1833–1870), American politicianCelia Applegate, American historianChristina Applegate (born 1971), American actressColleen Applegate, American actress known as Shauna GrantDan Applegate, American engineerDebby Applegate (born 1968), American historian and biographerDick Applegate, British army generalDouglas Applegate (born 1928), American politicianEddie Applegate (born 1935), American actorFred Applegate (1879–1968), American baseball playerFred Applegate (actor) (born 1953), American actor, singer and dancerJeremy Applegate (1965–2000), American actorJesse Applegate (1811-1888), American pioneerJessica-Jane Applegate (born 1996), British swimmerJodi Applegate (born 1964), American news anchorJoseph R. Applegate (1925–2003), American linguistK. A. Applegate (born 1956), American authorLindsay Applegate (1808–1892), American pioneerOliver Cromwell Applegate (1845-1938), American politicianRed Applegate (1921–1965), American boxerRex Applegate (1914-1998), American military close combat instructor in World War IIRoyce D. Applegate (1939-2003), American actor and screenwriterShannon Applegate, American historian