Applegate is an English surname. Notable people with the surname include:
Andrew J. Applegate (1833–1870), American politician
Celia Applegate, American historian
Christina Applegate (born 1971), American actress
Colleen Applegate, American actress known as Shauna Grant
Dan Applegate, American engineer
Debby Applegate (born 1968), American historian and biographer
Dick Applegate, British army general
Douglas Applegate (born 1928), American politician
Eddie Applegate (born 1935), American actor
Fred Applegate (1879–1968), American baseball player
Fred Applegate (actor) (born 1953), American actor, singer and dancer
Jeremy Applegate (1965–2000), American actor
Jesse Applegate (1811-1888), American pioneer
Jessica-Jane Applegate (born 1996), British swimmer
Jodi Applegate (born 1964), American news anchor
Joseph R. Applegate (1925–2003), American linguist
K. A. Applegate (born 1956), American author
Lindsay Applegate (1808–1892), American pioneer
Oliver Cromwell Applegate (1845-1938), American politician
Red Applegate (1921–1965), American boxer
Rex Applegate (1914-1998), American military close combat instructor in World War II
Royce D. Applegate (1939-2003), American actor and screenwriter
Shannon Applegate, American historian
