Appleby is a surname. Notable people with the surname include:
Anne Appleby (born 1954), American painter
Austin Appleby (born 1993), American football quarterback
Ben Appleby (1876–1961), English footballer
Fred Appleby (1879–1956), English long-distance runner
Jim Appleby (1934–2014), English footballer
Kim Appleby (born 1961), British singer
Louis Appleby, British psychiatrist
Melanie Appleby (1966–1990), British singer; sister of Kim
Shiri Appleby (born 1978), American actress
Stephen Appleby (1912–1984), British pilot
Stuart Appleby (born 1971), Australian golfer
Fictional characters:
Appleby (Catch-22), a character in the novel Catch-22
Sir Humphrey Appleby, a fictional character in the television series Yes, Minister
Sir John Appleby, a fictional detective created by Michael Innes