Neha Patil (Editor)

Apoptosis antagonizing transcription factor

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Species
  
Human

Entrez
  
26574

Human
  
Mouse

Ensembl
  
n/a

Aliases
  
AATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor

External IDs
  
MGI: 1929608 HomoloGene: 40811 GeneCards: AATF

Protein AATF is a protein that in humans is encoded by the AATF gene.

Contents

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Interactions

Apoptosis-antagonizing transcription factor has been shown to interact with:

  • PAWR,
  • POLR2J,
  • Retinoblastoma protein, and
  • Sp1 transcription factor.

    • References

    Apoptosis-antagonizing transcription factor Wikipedia
    (Text) CC BY-SA