Apfel (German for "apple") is a surname. Notable people with the surname include:
Arthur Apfel (born 1922), British figure skater
Holger Apfel (born 1970), leader of the National Democratic Party of Germany (NPD) in Saxony
Howard Apfel, (born 1962) American Rabbi and Cardiologist
Iris Apfel (born 1921), American businesswoman, former interior designer, and fashion icon
Kenneth S. Apfel (born 1948), 13th Commissioner of Social Security in the United States
Oscar Apfel (1878–1938), American film actor, film director, screenwriter and film producer