Anton Yuryev is famous Russian American scientist. He was awarded Ph.D at Johns Hopkins University for discovery of novel family of proteins interacting with C-terminal domain of RNA polymerase II holoenzyme using yeast two-hybrid screening. Sequence similarity of these proteins to splicing factors suggested the existence of physical coupling between transcription and post-transcriptional modification of messenger RNA. He continued his research as postdoctoral fellow at Novartis Pharmaceuticals where he demonstrated that mammalian ARAF protein kinase can be imported into mitochondria. During the completion of human genome sequencing he started working in the new emerging field of bioinformatics. While working at Orchid Biosciences between 2001 and 2003 he authored several algorithms for PCR primer design using statistical modeling. He is now working at Ariadne Genomics Inc where he is developing methods for computational pathway analysis. Anton Yuryev has edited several scientific books and numerous research articles.
Anton Yuryev was born in Moscow, Russia in 1966. He is son of Dmitri Furman, Russian political scientist, sociologist, and expert on religions.
Anton Yuryev is married to Alexandra Belenkaya. He has two daughters from the first marriage - Alisa Kasimova and Kristina Kasimova.
Dr. Anton Yuryev received his B.Sc in physics from Moscow Institute of Physics and Technology in 1987. Dr. Anton Yuryev received his Ph.D in Molecular Biology and Genetics from Johns Hopkins University in 1995.
Integrating fragmented software applications into holistic solutions: focus on drug discovery. Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi. Ong SY, Ng FL, Badai SS, Yuryev A, Alam M, J Integr Bioinform. 2010 Sep 23;7(1)
Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis. Ferlini A, Bovolenta M, Neri M, Gualandi F, Balboni A, Yuryev A, Salvi F, Gemmati D, Liboni A, Zamboni P, BMC Med Genet. 2010 Apr 28;11(1):64
Atlas of Signaling for Interpretation of Microarray experiments. Kotelnikova E, Ivanikova N, Kalinin A, Yuryev A, Daraselia N, PLoS One 2010, v5(2):e9256
Computational approaches for drug repositioning and combination therapy design. Kotelnikova EA, Yuryev A, Daraselia N. Journal of Bioinformatics and Computational Biology, J Bioinform Comput Biol. 2010 Jun;8(3):593-606
Yuryev A, Kotelnikova E, Daraselia N. Ariadne's ChemEffect and Pathway Studio knowledge base. Expert Opinion on Drug Discovery 2009, v4(12) 1307-1318
Yuryev A. In silico pathway analysis: the final frontier towards completely rational drug design. Expert Opinion on Drug Discovery 2008; v3(8):867-876(10)
Dunfield PF, Yuryev A, Senin P, Smirnova AV, Stott MB, Hou S, Ly B, Saw JH, Zhou Z, Ren Y, Wang J, Mountain BW, Crowe MA, Weatherby TM, Bodelier PL, Liesack W, Feng L, Wang L, Alam M. Methane oxidation by an extremely acidophilic bacterium of the phylum Verrucomicrobia. Nature. 2007 Dec 6;450(7171):879-82. Epub 2007 Nov 14.
Huang J, Yuryev A. Developing a statistical model for primer design. Methods Mol Biol. 2007; 402:105-38. Review.
Yuryev A. PCR primer design using statistical modeling. Methods Mol Biol. 2007; 402:93-104.
Kotelnikova E, Kalinin A, Yuryev A, and Maslov S. Prediction of Protein-protein Interactions on the Basis of Evolutionary Conservation of Protein Functions, Evolutionary Bioinformatics 2007: 3
Sivachenko AY, Yuryev A, Daraselia N, Mazo I. Molecular networks in microarray analysis. J Bioinform Comput Biol. 2007 Apr;5(2b):429-56.
Daraselia N, Yuryev A, Egorov S, Mazo I, Ispolatov I. Automatic extraction of gene ontology annotation and its correlation with clusters in protein networks. BMC Bioinformatics. 2007 Jul 10;8(1):243
Sivachenko A, Kalinin A, Yuryev A. Pathway analysis for design of promiscuous drugs and selective drug mixtures. Curr Drug Discov Technol. 2006 Dec;3(4):269-77
Sivachenko AY, Yuryev A. Pathway analysis software as a tool for drug target selection, prioritization and validation of drug mechanism. Expert Opinion on Therapeutic Targets, 2007 Mar;11(3):411-21
Yuryev A. Targeting transcription factors in cell regulation. Expert Opinion on Therapeutic Targets, 2006 June; Vol. 10, No. 3, 345-349
Ispolatov I, Mazo I, and Yuryev A. Finding mesoscopic communities in sparse networks. J. Stat. Mech., 2006 P09014.
Badretdinov A, Yuryev A, Pathway Analysis in Drug Development. Pharma & Bio Ingredients, March 2006
Yuryev A, Mulyukov Z, Kotelnikova E, Maslov S, Egorov S, Nikitin A, Daraselia N, Mazo I. Automatic pathway building in biological association networks. BMC Bioinformatics. 2006 Mar 24; 7:171.
Sivachenko AY, Yuryev A, Daraselia N, Mazo I. Identifying Local Gene Expression Patterns in Biomolecular Networks. IEEE Computational Systems Bioinformatics Conference, Aug. 8-11, 2005.
Ispolatov, I, Krapivsky, PL, Mazo I, Yuryev A. Cliques and duplication-divergence network growth. New J.Phys. 2005; 7:145
Ispolatov I, Yuryev A, Mazo I, Maslov S. Binding properties and evolution of homodimers in protein-protein interaction networks. Nucleic Acids Res. 2005 Jun 27;33(11):3629-35.
Edvardsen H, Irene Grenaker Alnaes G, Tsalenko A, Mulcahy T, Yuryev A, Lindersson M, Lien S, Omholt S, Syvanen AC, Borresen-Dale AL, Kristensen VN. Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds. Pharmacogenet Genomics. 2006 Mar;16(3):207-217.
Ispolatov, P.L.Krapivsky, Yuryev A. Duplication-divergence model of protein interaction network. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71
Daraselia N, Yuryev A, Egorov S, Novichkova S, Nikitin A, Mazo I. Extracting human protein interactions from MEDLINE using a full-sentence parser. Bioinformatics. 2004 Mar 22; 20(5): 604-11
Egorov S, Yuryev A, Daraselia N.T. A simple and practical dictionary-based approach for identification of proteins in Medline abstracts. J Am Med Inform Assoc. 2004 May-Jun;11(3):174-8.
Huang C-Yu, Studebaker J, Yuryev A, Huang J, Scott K, Kuebler J, Varde S. Alfisi S, Gelfand G, Pohl M, Boyce-Jacino MT. Auto-validation of fluorescent primer extension genotyping assay using signal clustering and neural networks. BMC Bioinformatics. 2004 Apr 02; 5(1): 36
Yuryev A, Huang J, Donaldson M, Pohl M, Patch R, Boyce-Jacino MT. Primer design and marker clustering for multiplex primer extension genotyping reaction using statistical modeling. Nucleic Acids Research, 2002, Vol. 30, No. 23 e131.
Yuryev A and Wennogle LP. Novel RAF kinase protein-protein interactions found by exhaustive yeast two-hybrid analysis. Genomics, 2003 Feb;81(2):112-25.
Yuryev A, Huang J, Pohl M, Patch R, Watson F, Bell P, Donaldson M, Phillips MS, and Boyce-Jacino MT. Predicting success of primer extension genotyping assay using statistical modeling. Nucleic Acid Research, 2002, Vol. 30, No. 23 e131.
Gorelenkov V, Antipov A, Lejnine S, Daraselia N, Yuryev A. A set of novel tools for PCR primer design. Biotechniques. 2001 Dec;31(6):1326-30.
Grant SF, Kristjansdottir H, Steinsson K, Blondal T, Yuryev A, Stefansson K, Gulcher JR. Long PCR detection of the C4A null allele in B8-C4AQ0-C4B1-DR3. J Immunol Methods. 2000 Oct 20;244(1-2):41-7.
Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP. Isoform-Specific Localization of A-RAF in Mitochondria. Mol Cell Biol. 2000 Jul 1; 20(13): 4870-4878.
Allentoff AJ, Mandiyan S, Liang H, Yuryev A, Vlattas I, Duelfer T, Sytwu II, Wennogle LP. Understanding the cellular uptake of phosphopeptides.
Cell Biochem Biophys. 1999; 31(2): 129-40.
Yuryev A, Wennogle LP. The RAF family: an expanding network of post-translational controls and protein-protein interactions. Cell Res 1998; 2: 81-98 (review)
Pellegrini MC, Liang H, Mandiyan S, Wang K, Yuryev A, Vlattas I, Sytwu T, Li Y-C, Wennogle LP. Mapping the substrate preferences of protein tyrosine phosphatase PTP-1B using combinatorial chemistry approaches. Biochemistry 1998; 8: 15598-15606.
Mandiyan S, Schumacher C, Cioffi C, Sharif H, Yuryev A, Lappe R, Monia B, Hanson S, Goff S, Wennogle LP. Molecular and cellular characterization of baboon C-Raf as a target for anti-proliferative effects of antisense oligonucleotides. Antisense Nuc Acid Drug Dev 1997; 6:539-548.
Yuryev A, Patturajan M, Litingtung Y, Joshi RV, Gentile C, Gebara M, Corden JL. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc Natl Acad Sci U S A 1996; 93(14): 6975-6980.
Yuryev A, and Corden JL. Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II. Genetics 1996; 143(2): 661-671.
Yuryev A, and Corden JL. A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yeast 1994;10 (5): 659-662.
Martin DR, Yuryev A, Kalli KR, Fearon DT, Ahearn JM. Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2. J Exp Med 1991; 174 (6): 1299-1311
Yuryev AD. Synthesis of Biotin Label and Combining it with oligonucleotide. Moscow Institute of Physics and Technology, Annual Reports, 1988 (in Russian)
Yuryev AD, Makarevich OI. Molecular Cloning of Na.K-TPase cDNA. Moscow Institute of Physics and Technology, Annual Reports, 1988 (in Russian)
