Lepere was studying architecture in Antwerp, when she was persuaded by her friends Dries van Noten and Olivier Theyskens to try modelling. She first appeared on the runways in Paris in 2000 and is currently signed with IMG Models. She also worked as a model for Delvaux and the Hugo Boss "Woman" and "Deep Red" perfumes, and with Steven Meisel, Mario Testino, Inez van Lamsweerde and Vinoodh Matadin. Lepere was on the covers of Vogue, Harper's Bazaar, Marie Claire, and French Playboy. She has her own line of jewellery.