Ann C. Palmenberg Wikipedia
Ann C. Palmenberg is a professor of virology and biochemistry at the University of Wisconsin-Madison. She received her B.S. from St. Lawrence University and her Ph.D. from the University of Wisconsin-Madison. Dr. Palmenberg has been given numerous awards for her research and involvement within the scientific community, such as Fellow for the American Academy of Microbiology. News articles have been published about her work within virology, including an article in the Milwaukee Journal Sentinel on her findings on the common cold.
Ann Palmenberg studies within the realms of Virology and Microbiology. She has invented several technologies for research in science, as well as been published several times within scientific journals and magazines, specifically related to her work with rhinovirus (the common cold). Ann Palmenberg works specifically with the genomics of viruses such as rhinovirus. Much of the research done by Dr. Palmenberg's research group relates to mutations made through protein synthesis and RNA translation of viruses. This type of research works toward finding a viral vaccines for constantly changing viruses, such as rhinovirus and HIV.
In addition to her research on rhinovirus, Dr. Palmenberg has done extensive research on encephalomyocarditis, which is a fatal viral disease that causes inflammation of skeletal and cardiac muscles, followed by degradation of these same muscles. This disease also causes the failure of reproductive organs. She has invented techniques that are used in order to further study encephalomyocarditis and its affects.
Along with her colleagues, Ann Palmenberg has invented the following research technologies, which are still in use today.Monoclonal Antibodies Against Cardiovirus Proteins is a technology that uses an antibody against encephalomyocarditis virus, which causes sudden death and reproductive failure. This virus specifically affects rodents, but can be transferred to other species. Ann Palmenberg and her colleagues developed the antibody, which is used to recognize the cardiovirus using such techniques as ELISA and Immunoprecipitation.
Compositions and Methods for Regulating mRNA Transcription and Translation is a technology that describes a translation enhancer. This can be used for an increase in proteins made from an IRES, while stopping the production of proteins that are not viral proteins. This is done by locating the nucleolus, binding to the ribosomes, and inhibiting mRNA translation.
Autocatalytic Cleavage Sites and their Use in a Protein Expression Vector is a technology that involves using cleavage sites found in picornaviruses in order to express recombinant peptides or proteins. This technique provides the potential for the creation of viral vaccines by inoculating the viral vector into a host cell, cleaving the foreign proteins and exposing the host to the antigenic protein.
Protein Inhibitor of Ran Activity and Methods of Use is a technology used in research with encephalomyocarditis. The Ran protein is important in the transportation of proteins and nucleic acids in and out of the nucleus. The encephalomyocarditis virus binds to the Ran protein, blocking the transportation of mRNAs out of the nucleus.
Method of Inhibiting Picornavirus Disease is a technique involving the use of a vaccine in order to stimulate the immune system to make antibodies against picornavirus. This technology is specifically used with research in picornavirus and mengovirus. It is used in monkeys and pigs.
Dr. Palmenberg has been an active member in the science community since 1975, with notable contributions in the following roles:Advisee Committee Member for The Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) in 2009
Member of the Executive Council for the American Society for Virology from 2007-2009
President of the American Society for Virology from 2007-2008
Representative for the American Society for Virology to the International Union of Microbiological Societies from 2005-2008
Co-Organizer in the 7th, 8th, and 9th International Symposium on Positive-Strand RNA Viruses in 2004, 2007, and 2010
Guest Editor for the Special Edition of Virus Research in 2003
FDA Site Visit Panelist for Laboratory of Methods Development in 2003
Current National and International Consultant on the Production and Use of Cell-Free Translation Systems
Current National and International Consultant on Protein Expression with Viral IRESes
Current National and International Consultant on Development and Assay of Recombinant Vaccines
Current National and International Consultant on Identification of Anti-Picornaviral Drugs Aimed at Specific Viral Proteases
Current National and International Consultant on Computer Based-Methods of Sequence Analysis, and Topological Assessments of RNA Folding Patterns
Member of the Executive Committee for the International Committee on Taxonomy of Viruses from 1999-2005
NIH Research Panelist on Polio Eradication in 1998
Advisory Board Member for the American Type Culture Collection, Virology Task Force, and Virology Journals from 1997-2002
Organizer for the American Society of Virology 13th and 20th Annual Meetings in Madison, WI from 1994-2001
Associate Editor for Virology Journal from 1993-2005
NIAID Task Force on Microbiology and Infectious Diseases in 1991
ASV Representative for International Committee on Taxonomy of Viruses in 1988-1992, 1999, and 2001-2002
Reviewer for Journal of Virology, Archives of Virology, Virology, Cell, Journal of Molecular Biology, EMBO Journal, PNAS, Science, Nature, Virus Research, and Biochemistry journals from 1975–Present
Ann Palmenberg has received several awards within the science community for her achievements, including the following:Made a Fellow of the American Academy of Microbiology in 2009
Elected as President for the American Society for Virology in 2007
Awarded the Distinguished Scientist Award from the University of Nebraska-Lincoln in 2006
Awarded an American Society for Virology Lifetime Membership in 2001
Elected Chair for the Institute of Molecular Virology at the University of Wisconsin-Madison from 1997-2013
Awarded the WARF Faculty Mid-Career Award from the University of Wisconsin-Madison in 1997
Awarded the Vilas Associate Award from the University of Wisconsin-Madison in 1996
Awarded the H.I. Romnes Faculty Research Award from the University of Wisconsin-Madison in 1991
Awarded the Pound Research Award from the University of Wisconsin-Madison in 1990
Awarded the Distinguished Scientist Award from the Waksman Institute of Rutgers University in 1989
Commended by Pan American Foot-and-Mouth Disease Center for Work in the Control and Eradication Programs in South America in 1988
The following are the most notable of her 93 publications for which Ann Palmenberg has been a major contributor.The Atomic Structure of Mengo Virus at 3.0 A Resolution
Proteolytic Processing of Picornaviral Polyprotein
Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveal Structure and Evolution
Sequence and Structural Elements that Contribute to Efficient Encephalomyocarditis Virus RNA Translation
The Nucleotide and Deduced Amino Acid sequences of the Encephalomyocarditis Viral Polyprotein Coding Region
(Text) CC BY-SA