Frame was born in Las Vegas, Nevada where at the age of 15 he dropped out of high school to build and run his first technology company, an ISP (Internet Service Provider), which later became the largest in Las Vegas.
Frame spent his early career working with network infrastructure. He joined Cisco Systems in 1997 at age 17 as a support engineer, and was eventually recruited to the Global Center of Expertise (GCOE) team with a focus on routing architecture. He received dual CCIE Certifications, a top technical certification at Cisco, during his first year with the company, making him the youngest person ever to earn this certification.
In 2001, Frame joined a core router start-up company called Procket Networks as a system test engineer. He remained with the firm until 2004, when he returned to his entrepreneurial roots and founded Ooma, a consumer VoIP company based in Palo Alto, CA.
Frame founded and began developing Ooma in 2005, backed by a strong team of technology executives including Mike Ramsey, creator of TiVo, the founding CEO of Ariba, Keith Krach, and Sean Parker, co-creator of Napster. By 2007, the company raised $27 million in funding from Draper Fisher Jurvetson and Worldview Partners among others. Members of the management team previously held roles at Yahoo, Sling Media, and Apple.
Frame also created an online course through Stanford University's Entrepreneurship Corner, where he offers students advice about launching a start-up business. Lesson topics range from recruiting a start-up team to creating a vision to raising start-up capital.
In March 2007, Andrew was named one of the "top entrepreneurs under the age of 30 most likely to shape the world's digital future" by the editors of Businessweek in a story titled, "Tech's Best Young Entrepreneurs, Tech's Next Gen: The Best and Brightest."
In 2009, Frame resigned his role as CEO of Ooma, naming Eric Stang as his replacement. That same year, he was named a TechFellow in the "Disruptive Innovation" category by TechCrunch.
In 2016, Andrew launched a mobile application called "Vigilante" designed to keep citizens aware of crime and to avoid active crime scenes. Andrew relaunched the app in 2017 under the new name "Citizen" after much critique of its original name.