Andrea Bertolini began racing karts at age 11. He came second in the Italian Championship, won championships at a national level, and went on to win the CIAK Cup and place second in the Italian 125 Championship in 2000. In 2001 he drove a Porsche 996 GT3-R for Art Engineering in the GT3 division of the FIA GT. In 2002 he moved to JMB Racing driving a Ferrari 360 Modena and continued through 2003 finishing 4th.
In 2004 he moved to the Giesse Squadra Corse team, again driving a 360 Modena. Once again, he placed 2nd overall, and was awarded the "Driver Performance of the Year". Part way through 2004, he was offered a position on the Maserati AF Corse team driving their new, GT1 class Maserati MC12, a car he had been involved in developing. He accepted, winning two races that year at Oschersleben, Germany and Zhuhai, China with his team mate, former Formula One driver, Mika Salo.
In 2005 he returned to JMB Racing, again driving an MC12. He finished the season tied 4th (with team mate Karl Wendlinger), within 4 points of first.
Andrea Bertolini also raced his MC12 in the American Le Mans Series (ALMS) in 2005 but without much success. He made no podium finishes and crashed out in the race at Mazda Raceway Laguna Seca.
For 2006 in the FIA GT, Bertolini moved to Vitaphone Racing Team where he again raced the MC12, with teammate Michael Bartels. Bartels and Bertolini finished first in the overall driver standings, and also their team to a 1st-place finish in the team standings.
Bertolini and Bartels also won the championship again driving the same Vitaphone Maserati in 2008, 2009 and 2010.
In 2011 he won the International Superstars Series driving a Maserati Quattroporte for Swiss Team.
Bertolini became the first person to drive Ferrari's new F1 Simulator at an opening ceremony held at the Italian teams' Maranello base.
For 2012, Bertolini will compete in the FIA World Endurance Championship, driving an AF Corse Ferrari 458 Italia GT2 with Olivier Beretta.
† There was no drivers championship that year, the result indicates team rank in the LMGTE Pro Trophy.
‡ As Bertolini was a guest driver, he was ineligible for championship points.
* Season still in progress.