Samiksha Jaiswal (Editor)

Amprenavir

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Covid-19
Trade names  Agenerase
MedlinePlus  a699051
Molar mass  505.628 g/mol
Protein binding  90%
AHFS/Drugs.com  Monograph
Routes of administration  Oral (capsules)
CAS ID  161814-49-9
Amprenavir FileAmprenavir skeletalsvg Wikimedia Commons
License data  EU EMA: Agenerase US FDA: Amprenavir
Pregnancy category  US: C (Risk not ruled out)

Amprenavir in a hiv protease active site


Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection. It was approved by the Food and Drug Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200 mg, delivered in 8 (eight) very large 150 mg gel capsules or 24 (twenty-four) 50 mg gel capsules twice daily.

Contents

Amprenavir Amprenavir HIV Protease inhibitor Read Reviews amp Product Use

Production of amprenavir was discontinued by the manufacturer on December 31, 2004; a prodrug version (fosamprenavir), is available.

Amprenavir meaning


Background

Amprenavir Amprenavir Wikipedia

Research aimed at development of renin inhibitors as potential antihypertensive agents had led to the discovery of compounds that blocked the action of this peptide cleaving enzyme. The amino acid sequence cleaved by renin was found to be fortuitously the same as that required to produce the HIV peptide coat. Structure–activity studies on renin inhibitors proved to be of great value for developing HIV protease inhibitors. Incorporation of an amino alcohol moiety proved crucial to inhibitory activity for many of these agents. This unit is closely related to the one found in the statine, an unusual amino acid that forms part of the pepstatin, a fermentation product that inhibits protease enzymes.

Amprenavir AMPRENAVIR 161814499
Amprenavir Amprenavir Ganfyd
Amprenavir Agenerase Capsules Amprenavir Capsules Side Effects Interactions

References

Amprenavir Wikipedia


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