EC number 3.1.1.29 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9054-98-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an aminoacyl-tRNA hydrolase (EC 3.1.1.29) is an enzyme that catalyzes the chemical reaction
N-Substituted aminoacyl-tRNA + H2OThus, the two substrates of this enzyme are N-Substituted aminoacyl-tRNA and H2O, whereas its two products are N-substituted amino acid and tRNA.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RYB, 1WN2, 1XTY, 2D3K, 2E1B, 2PTH, 2Z2I, 2Z2J, and 2Z2K.
References
Aminoacyl-tRNA hydrolase Wikipedia(Text) CC BY-SA