Amino acid response (AAR) is the mechanism triggered in mammalian cells by amino acid starvation.
Contents
The amino acid response pathway is triggered by shortage of any essential amino acid, and results in an increase in activating transcription factor ATF4, which in turn affect many process by sundry pathways to limit or increase the production of other proteins.
Proteins increased by AAR
Leucine starvation
PCAF is recruited specifically to the CHOP amino acid response element (AARE) to enhance the ATF4 transcriptional activity.
References
Amino acid response Wikipedia(Text) CC BY-SA