EC number 3.1.3.73 ExPASy NiceZyme view | CAS number 251991-06-7 | |
The primary biochemical reaction catalyzed by the adenosylcobalamin-5'-phosphate phosphatase(formerly: alpha-ribazole phosphatase) (EC 3.1.3.73) enzyme is
This enzyme can also catalyze the following reaction in vitro, however it is not the biologically relevant reaction
alpha-ribazole 5'-phosphate + H2OThus, the two substrates of this enzyme are adenosylcobalamin-5'-phosphate and H2O, whereas its two products are adenosylcobalamin and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is adenosylcobalamin-5'-phosphate phosphohydrolase. This enzyme is also called CobC. This enzyme participates in adenosylcobalamin (coenzyme B12) biosynthesis.
Structural studies
As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 2ENU, 2ENW, 2EOA, 2OWE, 2P2Y, 2P2Z, 2P30, 2P6M, 2P6O, 2P75, 2P77, 2P78, 2P79, 2P9Y, 2P9Z, and 2PA0.