ATC code C02CA | Biological target α-adrenoceptors | |
Use • hypertension
• vasoconstriction
• BPH Mechanism of action • Receptor antagonist
• Inverse agonist | ||
Alpha-blockers or α-blockers are pharmacological agents that act as neutral antagonists or inverse agonists of α-adrenergic receptors (α-adrenoceptors).
Contents
Classification
When the term "alpha blocker" is used without further qualification, it sometimes refers to α1-blockers, and sometimes refers to agents that act at both types of receptors.
Examples of non-selective α-adrenergic receptor antagonists include:
Selective α1-adrenergic receptor antagonists include:
Selective α2-adrenergic receptor antagonists include:
The agents carvedilol and labetalol are both α- and β-blockers.
Uses
α-Blockers are used in the treatment of several conditions, such as Raynaud's disease, hypertension, and scleroderma.
α-Blockers can also be used to treat anxiety and panic disorders, such as generalized anxiety disorder, panic disorder, or posttraumatic stress disorder (PTSD). While most commonly used to treat hypertension (usually in conjunction with diuretics when other treatments are ineffective), they are also often used to treat the symptoms of BPH (benign prostatic hyperplasia).