Levine attended the University of Leeds where she met future My Dad Wrote a Porno collaborators Jamie Morton and James Cooper. She had been an active part of LSTV, the University's TV station.
Levine was voted "Best On-Screen Female" at the National Student Television Awards in 2008. Levine has presented backstage coverage at The BRIT Awards and the EMAs for MTV and presented The Hot Desk on ITV2.
Levine hosted Big Brother's Bit on the Side with Jamie East, from the reality show's revival in 2011 on Channel 5, until 2013 when the pair departed the show. During this time, she was one of the voices of 'Big brother' herself, which included talking to housemates in the diary room and announcing tasks and news to the housemates. She also has worked on Pop Up Pop Quiz as well as hosting Celebrity Bites on MTV.
On 7 January 2013, Levine joined BBC Radio 1 to present a show with Phil Taggart. The show aired from 10pm until midnight on Mondays to Thursdays. In August 2014 she left her weeknight slot with Taggart to present a solo weekend afternoon show on the station (1300-1600) taking over from Huw Stephens. As well as her own show, Levine is a semi-regular cover presenter on weekdays, for shows such as The Radio 1 Drivetime Show with Greg James and Scott Mills.
On 31 October 2013, Levine appeared on BBC Radio 1's Innuendo Bingo.
Levine takes part in the monthly column, the 'Food Club' with Laura Jackson for Company magazine.
On 16 November 2014, it was announced that Levine, along with several other celebrities and choirmaster Gareth Malone had reached Number 1 in the UK music chart with their cover of Avicii's 'Wake Me Up' in aid of the charity Children In Need.
As of 2015, she has been one of the three presenters of the podcast My Dad Wrote a Porno.
In February 2017, Levine presented backstage at the BRIT Awards for ITV2. In May of the same year, she recorded an episode of the fifteenth series of QI.
In 2008, Levine won the National Student Television Award for "Best On-Screen Female"Television