Nationality Iran-Canada-USA | Role Engineer Name Ali Khademhosseini | |
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Fields Biomedical Engineering, Biomaterials, Tissue Engineering Institutions Harvard Medical School, Massachusetts Institute of Technology Alma mater Massachusetts Institute of Technology, University of Toronto Notable awards American Association for the Advancement of Science (AAAS) Fellow (2014) National Academy of Sciences Kavli Frontiers of Science Fellow (2012) Presidential Early Career Award for Scientists and Engineers (2011) Society for Biomaterials Young Investigator Award (2011) TERMIS-NA Young Investigator Award (2010); American Institute for Chemical Engineers (AIChE) Allan F. Colburn Award (2010); ACS Colloid and Surface Science Division Unilever Award (2010); Office of Naval Research Young Investigator Award (2010); Association for Lab Automation (ALA) Innovation Award (2010); International Academy for Medical and Biological Engineering (IAMBE) Award for Young Faculty Members (2009); University of Toronto Engineering alumni’s class of 7T6 award (2009); NSF Career Award (2009); IEEE/EMBS Early career award (2008); Technology Review Magazine TR35 Top Young Innovator (2007); BMW Scientific Award (2007); Coulter Foundation Early Career (2006)-national award for biomedical engineering; Outstanding Researcher in Polymer Science by OMNOVA / MIT (2005); Outstanding Research by Biomedical Engineering Society (2005)- national award;
Outstanding Research Mentor at MIT (2004)- university award for mentoring; Education University of Toronto, Massachusetts Institute of Technology | ||
Doctoral advisor Robert S. Langer Residence United States of America | ||
Tissue engineering applied to cancer ali khademhosseini
Ali Khademhosseini (born October 30, 1975, Tehran, Iran) is the Director of the Biomaterials Innovation Research Center (BIRC), Professor at Harvard Medical School (HMS), is a faculty member at the Harvard-MIT Division of Health Sciences and Technology (HST), Brigham and Women’s Hospital (BWH), and is an associate faculty at the Wyss Institute for Biologically Inspired Engineering. Dr. Khademhosseini is also an Associate Editor for ACS Nano. Previously, he served as the Research Highlights editor for Lab on a Chip. He is on the editorial boards of numerous journals including Small, RSC Advances, Advanced Healthcare Materials, Biomaterials Science, Journal of Tissue Engineering and Regenerative Medicine, Biomacromolecules, Reviews on Biomedical Engineering, Biomedical Materials, Journal of Biomaterials Science-Polymer Edition and Biofabrication. He is a standing member of the NIH BTSS (Bioengineering, Technology and Surgical Sciences) study section. He has edited multiple books / journal special issues and is an author on >500 peer-reviewed journal articles, editorials and review papers, >60 book chapters/edited books and >20 patent/disclosure applications. His work has been published in leading journals and is routinely highlighted in international media. He has been cited >32,000 times and has an H-index of 95. Also, he has given over >250 invited seminars and keynote lectures. In 2014, 2015, and 2016 he was also selected by Thomson Reuters as one of the World’s Most Influential Minds.
Contents
- Tissue engineering applied to cancer ali khademhosseini
- 3d bioprinting applied for tissue engineering ali khademhosseini
- Background and Personal Life
- Contributions to Medicine and Science
- Academic Mentoring
- Awards and Honors
- References
3d bioprinting applied for tissue engineering ali khademhosseini
Background and Personal Life
Khademhosseini was born in Tehran, Iran, and grew up in Toronto, Canada. He received his Ph.D. in bioengineering from MIT under the supervision of Robert S. Langer (2005), and MASc (2001) and BASc (1999) degrees from University of Toronto both in chemical engineering. Khademhosseini currently lives in Cambridge, MA, and is married.
Contribution's to Medicine and Science
Khademhosseini has pioneered the design and development of a variety of hydrogels for regenerative medicine and medical device applications. These hydrogels encompass light-sensitive naturally-derived proteins, shear-thinning biomaterial gels, and surgical sealants, each of which has opened new horizons for tissue engineering, minimally invasive medical procedures, and advanced biomedicine.
Khademhosseini has popularized the usage of a photocrosslinkable gelatin derivatives. Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications, due to their suitable biological properties, and tunable physical properties. Three dimensional (3D) GelMA hydrogels closely resemble the native extracellular matrix (ECM), due to the presence of cell-binding sites, and matrix metalloproteinase responsive peptide motifs, which allow cells to remodel and proliferate within the GelMA-based scaffolds. A second class of hydrogels pioneered by the group is a nanosilicate-based shear thinning gel that could be easily injected in a minimally invasive medical procedure.
Khademhosseini has further expanded his contribution in the field of biomedical adhesives by developing an elastic and adhesive hydrogels for surgical applications. These hydrogels are highly mechanically elastic and can adhere strongly to injured tissues (such as lung) to protect the tissue and promote its regeneration by allowing cell infiltration, growth, and differentiation.
Khademhosseini also developed ‘organ-on-a-chip’ systems that aim to mimic human responses to various chemicals in vitro. By merging the advances in microfluidics with microfabrication technologies, he has introduced novel platforms that lead to the creation of organ functions on a single chip. Within these platforms, microengineering enables precise control over the cellular microenvironment, whereas microfluidics provides an ability to perfuse the constructs on a chip and to connect individual sections with each other. This approach results in microsystems that may better represent the in vivo environment. These organ-on-a-chip platforms can be utilized for developing disease models as well as for conducting drug testing studies.
Academic Mentoring
As a recipient of MIT’s Outstanding Undergraduate mentor award (2004) and Brigham Women’s Hospital senior faculty mentor award (2016). Dr. Khademhosseini is highly interested in training students and postdoctoral fellows in his laboratory. Over 40+ of his previous trainees and fellows have gone into academia as faculty at institutions including Harvard University-Massachusetts General Hospital, Brigham and Women’s Hospital, University of California-Riverside, Arizona State University, Texas A&M University, University of Pittsburgh, INSERM, Northeastern University, Hanyang University, Singapore National University and Tsinghua University
Awards and Honors
Khademhosseini’s interdisciplinary research has been recognized by over 40 major national and international awards. He is one of the recipients of the 2011 Presidential Early Career Award for Scientists and Engineers (PECASE) by President Barack Obama. He has also received early career awards from three major engineering discipline societies: electrical (IEEE Engineering in Medicine and Biology award / IEEE Nanotechnology award), chemical (AIChE Colburn award) and mechanical engineering (ASME YC Fung award). In addition, he has received the young investigator awards of the Society for Biomaterials and the Tissue Engineering and Regenerative Medicine International Society-North America. He has also received the American Chemical Society’s Viktor K. Lamer award and the Unilever award and has been recognized by major governmental awards including the NSF Career award and the Office of Naval Research young investigator award. In 2007, he was named a TR35 recipient by the Technology Review Magazine as one of the world’s top young innovators. He received the TR35 based on his work on developing 'living legos' that can be used to make artificial organs. He received the Tissue Engineering and Regenerative Medicine International Society-North America's senior investigator award based on his contributions to the field. In 2017, he received the Clemson Award for his contributions to literature from the Society for Biomaterials. He has also received major recognitions from other organizations including the Society for Laboratory Automation and Screening Innovation Award, a Sloan fellowship as well as the IAMBE and the Coulter foundation early career awards. For his Ph.D. work he received the BMW Scientific Award. He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), Biomedical Engineering Society (BMES), Royal Society of Chemistry (RSC), Biomaterials Science and Engineering (FBSE), NANOSMAT Society and American Association for the Advancement of Science (AAAS).