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Alexander Macdonald, 1st Baron Macdonald (c. 1745-12 September 1795), was a Scottish peer.
Macdonald was the younger son of Sir Alexander Macdonald, 7th Baronet, and his wife Lady Margaret (née Montgomerie). He was educated at Eton and served with the Grenadier Guards. Macdonald was also a Deputy Lieutenant of Inverness-shire and a Brigadier-General in the Royal Company of Archers. He succeeded his elder brother in the baronetcy in 1766 and in 1776 he was raised to the Peerage of Ireland as Baron Macdonald, of Slate in the County of Antrim.
Lord Macdonald married Elizabeth Diana Bosville, daughter of Godfrey Bosville, in 1768. They had seven sons and three daughters. Lady Macdonald died in 1789. Lord Macdonald survived ber by six years and died in September 1795. He was succeeded in his titles by his son Alexander.