Rahul Sharma (Editor)

Adenosine A2B receptor

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Species
  
Human

Entrez
  
136

Human
  
Mouse

Ensembl
  
ENSG00000170425

Adenosine A2B receptor

Aliases
  
ADORA2B, ADORA2, adenosine A2b receptor

External IDs
  
MGI: 99403 HomoloGene: 20167 GeneCards: ADORA2B

The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it.

Contents

Mechanism

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene

The gene is located near the Smith-Magenis syndrome region on chromosome 17.

Ligands

Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing.

Agonists

  • BAY 60-6583
  • NECA (N-ethylcarboxamidoadenosine)
  • (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes
  • LUF-5835
  • LUF-5845 - partial agonist

    • Antagonists and inverse agonists

  • Compound 38: antagonist, high affinity and good subtype selectivity
  • ATL-801
  • CVT-6883
  • MRS-1706
  • MRS-1754
  • OSIP-339,391
  • PSB-603
  • PSB-0788
  • PSB-1115

    • References

    Adenosine A2B receptor Wikipedia
    (Text) CC BY-SA