Adenosine A2B receptor

Updated on Dec 08, 2024

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Species Human Entrez 136		Human Mouse Ensembl ENSG00000170425

Aliases ADORA2B, ADORA2, adenosine A2b receptor External IDs MGI: 99403 HomoloGene: 20167 GeneCards: ADORA2B

The adenosine A_2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A_2b receptor gene which encodes it.

Mechanism

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene

The gene is located near the Smith-Magenis syndrome region on chromosome 17.

Ligands

Research into selective A_2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A_2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing.

Agonists

BAY 60-6583

NECA (N-ethylcarboxamidoadenosine)

(S)-PHPNECA - high affinity and efficacy at A_2B, but poor selectivity over other adenosine receptor subtypes

LUF-5835

LUF-5845 - partial agonist

Antagonists and inverse agonists

Compound 38: antagonist, high affinity and good subtype selectivity

ATL-801

CVT-6883

MRS-1706

MRS-1754

OSIP-339,391

PSB-603

PSB-0788

PSB-1115

References

Adenosine A2B receptor Wikipedia

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