Adam Friedrich Graf von Seinsheim (1708–1779) was the Prince-Bishop of Wurzburg from 1755 to 1779 and Prince-Bishop of Bamberg from 1757 to 1779.
Adam Friedrich von Seinsheim was born in Regensburg on 16 February 1708, the son of Maximilian Franz Graf von Seinsheim (1681-1739) and his wife Anna Philippina Grafin von Schonborn (1685-1721). His mother was the sister of Franz Georg von Schonborn, Archbishop-Elector of Trier; Friedrich Karl von Schonborn, Prince-Bishop of Bamberg and Wurzburg; and Damian Hugo Philipp von Schonborn, Prince-Bishop of Speyer.
He became a canon of Bamberg Cathedral and Wurzburg Cathedral in 1718. He studied Christian theology at the University of Salzburg (master's degree 1724) and at the Collegium Germanicum 1725-27; and law at the University of Wurzburg and Leiden University. In 1747, he became provost of the Church of St. Gangolf in Bamberg. He was ordained as a priest on 29 September 1753.
The cathedral chapter of Wurzburg Cathedral unanimously elected him Prince-Bishop of Wurzburg on 7 January 1755, with Pope Benedict XIV confirming his appointment on 17 March 1755. He was consecrated as a bishop by Cardinal Franz Christoph von Hutten zu Stolzenfels, Prince-Bishop of Speyer, on 15 June 1755. At the insistence of Francis I, Holy Roman Emperor, he was elected Prince-Bishop of Bamberg on 21 April 1757, thus creating a personal union between the Prince-Bishopric of Wurzburg and the Prince-Bishopric of Bamberg. The pope confirmed this appointment on 23 May 1757.
Adam Friedrich von Seinsheim supported the imperial side during the Seven Years' War. Troops from the Kingdom of Prussia invaded both bishoprics during the course of this war.
He died of pneumonia in Wurzburg on 18 February 1779 and is buried there.