Species Human Entrez 87 | Human Mouse Ensembl ENSG00000072110 | |
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Aliases ACTN1, BDPLT15, actinin alpha 1 External IDs MGI: 2137706 HomoloGene: 55553 GeneCards: ACTN1 | ||
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Contents
Function
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.
Interactions
Actinin, alpha 1 has been shown to interact with:
