ATC code None ChemSpider 8490316
HCl: 24621155 | PubChem CID 10314851
HCl: 12782338 | |
 | ||
Legal status CA: Schedule I
UK: Class A
Illegal in Sweden CAS Number 82003-75-6
HCl: 79279-03-1 UNII T64K7YD33B
HCl: QY70U25H9M | ||
Acrylfentanyl (also known as acryloylfentanyl) is a highly potent opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug. In animal studies the IC50 or half maximal inhibitory concentration for acrylfentanyl to displace naloxone is 1.4 nM, being slightly more potent than fentanyl itself (1.6 nM) as well as having a longer duration of action.
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Side effects
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. Acrylamide is generally avoided in drug discovery due to its probable neurotoxicity and carcinogenicity.
Acrylfentanyl has been linked to 20 deaths in Sweden as well as two deaths in Denmark in summer 2016.
Legal status
As of 16 August 2016, acrylfentanyl is illegal in Sweden.