Puneet Varma (Editor)


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ATC code  None
ChemSpider  8490316 HCl: 24621155
PubChem CID  10314851 HCl: 12782338
Acrylfentanyl httpspubchemncbinlmnihgovimageimageflycg
Legal status  CA: Schedule I UK: Class A Illegal in Sweden
CAS Number  82003-75-6 HCl: 79279-03-1
UNII  T64K7YD33B HCl: QY70U25H9M

Acrylfentanyl (also known as acryloylfentanyl) is a highly potent opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug. In animal studies the IC50 or half maximal inhibitory concentration for acrylfentanyl to displace naloxone is 1.4 nM, being slightly more potent than fentanyl itself (1.6 nM) as well as having a longer duration of action.


Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. Acrylamide is generally avoided in drug discovery due to its probable neurotoxicity and carcinogenicity.

Acrylfentanyl has been linked to 20 deaths in Sweden as well as two deaths in Denmark in summer 2016.

Legal status

As of 16 August 2016, acrylfentanyl is illegal in Sweden.


Acrylfentanyl Wikipedia

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