Neha Patil (Editor)

Acetylglutamate kinase

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EC number
  
2.7.2.8

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9027-58-1

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, an acetylglutamate kinase (EC 2.7.2.8) is an enzyme that catalyzes the chemical reaction:

Contents

ATP + N-acetyl-L-glutamate ⇌ ADP + N-acetyl-L-glutamyl 5-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-L-glutamate, whereas its two products are ADP and N-acetyl-L-glutamyl 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. This enzyme participates in urea cycle and metabolism of amino groups.

Nomenclature

The systematic name of this enzyme class is ATP:N-acetyl-L-glutamate 5-phosphotransferase. Other names in common use include:

  • N-acetylglutamate 5-phosphotransferase,
  • acetylglutamate phosphokinase,
  • N-acetylglutamate phosphokinase,
  • N-acetylglutamate kinase, and
  • N-acetylglutamic 5-phosphotransferase.

    • Structural studies

    As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1GS5, 1GSJ, 1OH9, 1OHA, 1OHB, 2AP9, 2BTY, 2BUF, and 2RD5.

    References

    Acetylglutamate kinase Wikipedia
    (Text) CC BY-SA


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