Supriya Ghosh

AZIN1

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Species  Human
Entrez  51582
Human  Mouse
Ensembl  ENSG00000155096
AZIN1
Aliases  AZIN1, AZI, AZIA1, OAZI, OAZIN, ODC1L, antizyme inhibitor 1
External IDs  MGI: 1859169 HomoloGene: 22933 GeneCards: AZIN1

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.

References

AZIN1 Wikipedia


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