Samiksha Jaiswal

AUP1

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Species  Human
Entrez  550
Human  Mouse
Ensembl  ENSG00000115307
AUP1
Aliases  AUP1, ancient ubiquitous protein 1
External IDs  MGI: 107789 HomoloGene: 7239 GeneCards: AUP1

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.

Contents

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

Interactions

AUP1 has been shown to interact with ITGA2B.

References

AUP1 Wikipedia


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