Trisha Shetty

ATP:guanido phosphotransferase family

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Symbol  ATP-gua_Ptrans
Pfam clan  CL0286
PROSITE  PDOC00103
Pfam  PF00217
InterPro  IPR022414
SCOP  1crk
ATP:guanido phosphotransferase family

In molecular biology, the ATP:guanido phosphotransferase family is a family of structurally and functionally related enzymes, that reversibly catalyse the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include:

  • Glycocyamine kinase (EC 2.7.3.1), which catalyses the transfer of phosphate from ATP to guanidoacetate.
  • Arginine kinase (EC 2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine.
  • Taurocyamine kinase (EC 2.7.3.4), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to taurocyamine.
  • Lombricine kinase (EC 2.7.3.5), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine.
  • Smc74, a cercaria-specific enzyme from Schistosoma mansoni.
  • Creatine kinase (EC 2.7.3.2) (CK), which catalyses the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP.
  • Creatine kinase plays an important role in energy metabolism of vertebrates. There are at least four different, but very closely related, forms of CK. Two isozymes, M (muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchins there is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.

    ATP:guanido phosphotransferases contain a C-terminal catalytic domain which consists of a duplication where the common core consists of two beta-alpha-beta2-alpha repeats. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain. They also contain an N-terminal domain which has an all-alpha fold consisting of an irregular array of 6 short helices.

    References

    ATP:guanido phosphotransferase family Wikipedia


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