| ATG16L1, autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1|
MGI: 1924290 HomoloGene: 41786 GeneCards: ATG16L1
Autophagy-related protein 16-1 is a protein that in humans is encoded by the ATG16L1 gene.
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.
Mutations in the ATG16L1 gene may be linked to Crohn's disease.