Neha Patil (Editor)

ATG16L1

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Covid-19
Species  Human
Entrez  55054
Human  Mouse
Ensembl  n/a
ATG16L1
Aliases  ATG16L1, autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1
External IDs  MGI: 1924290 HomoloGene: 41786 GeneCards: ATG16L1

Autophagy-related protein 16-1 is a protein that in humans is encoded by the ATG16L1 gene.

Contents

Function

Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.

Clinical significance

Mutations in the ATG16L1 gene may be linked to Crohn's disease.

References

ATG16L1 Wikipedia


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