Species Human Entrez 55054 | Human Mouse Ensembl n/a | |
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Aliases ATG16L1, autophagy related 16-like 1 (S. cerevisiae), APG16L, ATG16A, ATG16L, IBD10, WDR30, autophagy related 16 like 1 External IDs MGI: 1924290 HomoloGene: 41786 GeneCards: ATG16L1 | ||
Autophagy-related protein 16-1 is a protein that in humans is encoded by the ATG16L1 gene.
Contents
Function
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.
Clinical significance
Mutations in the ATG16L1 gene may be linked to Crohn's disease.
References
ATG16L1 Wikipedia(Text) CC BY-SA