Kalpana Kalpana (Editor)


Updated on
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Aliases  ATF3
Human  Mouse
Ensembl  ENSG00000162772
Species  Human
Entrez  467
ATF3 wwwnaturecomnaturejournalv441n7090imagesna

External IDs  MGI: 109384 HomoloGene: 1265 GeneCards: ATF3

Atf3 matem tica

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.



ATF3 Frontiers Activating Transcription Factor 3 and the Nervous System

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Clinical significance

ATF3 Genatlas sheet

ATF-3 is induced upon physiological stress in various tissues. It is also a marker of regeneration following injury of dorsal root ganglion neurons in Pain Research.


ATF3 has been shown to interact with:

  • C-jun,
  • DDIT3
  • JunD,
  • P53, and
  • SMAD3.

  • ATF3 ATF3 activating transcription factor 3

    ATF3 HDL suppresses TLR ligandinduced inflammation via activation of

    ATF3 Genatlas sheet

    ATF3 ATF3 activating transcription factor 3


    ATF3 Wikipedia