Aliases ATF3 Human Mouse Ensembl ENSG00000162772 | Species Human Entrez 467 | |
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External IDs MGI: 109384 HomoloGene: 1265 GeneCards: ATF3 | ||
Atf3 matem tica
Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.
Contents
Transcription factor atf3 links host adaptive response to breast cancer metastasis
Function
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Clinical significance
ATF-3 is induced upon physiological stress in various tissues. It is also a marker of regeneration following injury of dorsal root ganglion neurons in Pain Research.
Interactions
ATF3 has been shown to interact with:
