Puneet Varma

ARL4D

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Species  Human
Entrez  379
Human  Mouse
Ensembl  ENSG00000175906
ARL4D
Aliases  ARL4D, ARF4L, ARL6, ADP ribosylation factor like GTPase 4D
External IDs  MGI: 1933155 HomoloGene: 1255 GeneCards: ARL4D

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

Contents

Function

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet–Biedl syndrome (BBS).

Model organisms

Model organisms have been used in the study of ARL4D function. A conditional knockout mouse line, called Arl4dtm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and significant abnormalities were observed. Homozygous mutant females had decreased bone mineral content, heart weight, lean body mass and CD8-positive, alpha-beta memory T cell number. Males had abnormal rib morphology with vertebral transformation. Both sexes displayed a reduction in dorsal third ventricle area and hippocampal area.

References

ARL4D Wikipedia


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