Species Human Entrez 400 | Human Mouse Ensembl ENSG00000120805 | |
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Aliases ARL1, ARFL1, ADP ribosylation factor like GTPase 1 External IDs MGI: 99436 HomoloGene: 20319 GeneCards: ARL1 | ||
ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.
Contents
Function
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
Interactions
ARL1 has been shown to interact with GOLGA4 and GOLGA1.
References
ARL1 Wikipedia(Text) CC BY-SA