| ARL1, ARFL1, ADP ribosylation factor like GTPase 1|
MGI: 99436 HomoloGene: 20319 GeneCards: ARL1
ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
ARL1 has been shown to interact with GOLGA4 and GOLGA1.