Entrez 51742 | Ensembl ENSG00000054267 | |
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Aliases ARID4B, BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180, AT-rich interaction domain 4B External IDs MGI: 2137512 HomoloGene: 12847 GeneCards: ARID4B | ||
AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.
Function
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.
References
ARID4B Wikipedia(Text) CC BY-SA