Samiksha Jaiswal

ARID1B

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Species  Human
Entrez  57492
Human  Mouse
Ensembl  ENSG00000049618
ARID1B
Aliases  ARID1B, 6A3-5, BAF250B, BRIGHT, DAN15, ELD/OSA1, MRD12, OSA2, P250R, CSS1, AT-rich interaction domain 1B
External IDs  MGI: 1926129 HomoloGene: 32344 GeneCards: ARID1B

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

Contents

Clinical significance

Germline mutations in ARID1B are associated with Coffin-Siris syndrome. Somatic mutations in ARID1B are associated with several cancer subtypes, suggesting that it is a tumor suppressor gene.

Interactions

ARID1B has been shown to interact with SMARCA4 and SMARCA2.

References

ARID1B Wikipedia


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