Species Human Entrez 57514 | Human Mouse Ensembl ENSG00000031081 | |
Aliases ARHGAP31, AOS1, CDGAP, Rho GTPase activating protein 31 External IDs MGI: 1333857 HomoloGene: 10644 GeneCards: ARHGAP31 | ||
The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.
Contents
Function
ARHGAP31 encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth.
Clinical relevance
ARHGAP31 mutations result in a loss of available active Cdc42 and consequently disrupt actin cytoskeletal structures, causing syndromic cutis aplasia and limb anomalies.
References
ARHGAP31 Wikipedia(Text) CC BY-SA