Entrez 27350 | Ensembl ENSG00000244509 | |
Aliases APOBEC3C, A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3, apolipoprotein B mRNA editing enzyme catalytic subunit 3C External IDs HomoloGene: 129856 GeneCards: APOBEC3C | ||
Probable DNA dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene. APOBEC3C (A3C) was reported to inhibit simian immunodeficiency deficiency virus potently rather than HIV-1, in absence of viral infectivity factor, Vif.
Contents
Function
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
Structure
The crystal structure of A3C suggests a putative HIV-1 vif binding region. A3C was found to inhibit LINE-1 elements by directly interacting with ORF1p proteins, in a deaminase-indepedent manner.