Girish Mahajan

APBA1

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Species  Human
Entrez  320
Human  Mouse
Ensembl  n/a
APBA1
Aliases  APBA1, D9S411E, LIN10, MINT1, X11, X11A, X11ALPHA, amyloid beta precursor protein binding family A member 1
External IDs  MGI: 1860297 HomoloGene: 897 GeneCards: APBA1

Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.

Contents

Function

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.

Interactions

APBA1 has been shown to interact with KCNJ12, CCS, CASK and Amyloid precursor protein.

References

APBA1 Wikipedia


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