Species Human Entrez 1173 | Human Mouse Ensembl ENSG00000161203 | |
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Aliases AP2M1, AP50, CLAPM1, mu2, adaptor related protein complex 2 mu 1 subunit External IDs MGI: 1298405 HomoloGene: 3000 GeneCards: AP2M1 | ||
AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.
Contents
Function
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
AP2M1 has been shown to interact with CTLA-4 and Alpha-1B adrenergic receptor.
References
AP2M1 Wikipedia(Text) CC BY-SA