Samiksha Jaiswal

ANXA11

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Species  Human
Entrez  311
Human  Mouse
Ensembl  ENSG00000122359
ANXA11
Aliases  ANXA11, ANX11, CAP50, annexin A11
External IDs  MGI: 108481 HomoloGene: 22759 GeneCards: ANXA11

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

Contents

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.

Interactions

ANXA11 has been shown to interact with PDCD6 and ALG2.

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder.

References

ANXA11 Wikipedia


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