Entrez 51434 | Ensembl ENSG00000196510 | |
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Aliases ANAPC7, APC7, anaphase promoting complex subunit 7 External IDs MGI: 1929711 HomoloGene: 10512 GeneCards: ANAPC7 | ||
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Contents
Function
This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.
Interactions
ANAPC7 has been shown to interact with ANAPC1, ANAPC4, CDC27 and CDC20.
References
ANAPC7 Wikipedia(Text) CC BY-SA