Samiksha Jaiswal (Editor)

AM 938

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Covid-19
CAS Number  303113-08-8
ChemSpider  8821567
3D model (Jmol)  Interactive image
PubChem CID  10646208
Formula  C27H40O4
Molar mass  428.603 g/mol
AM-938

AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3nM at CB2 and 1.2nM at CB1, a selectivity of around 4x.

References

AM-938 Wikipedia


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