Girish Mahajan

AM 694

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CAS Number  335161-03-0
ChemSpider  8064843
3D model (Jmol)  Interactive image
PubChem CID  9889172
Formula  C20H19FINO
Molar mass  435.273 g/mol
AM-694 httpswwwrechemcotomediacatalogproductcach
Legal status  AU: S9 (Prohibited) CA: Schedule II DE: Anlage II (Prohibited) US: Schedule I

AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors. No public data about AM-694 metabolism is known. AM-694 has already emerged as a designer drug.

Contents

Pharmacology

AM-694 is an agonist for cannabinoid receptors. Affinities are: with a Ki of 0.08 nM at CB1 and 18x selectivity over CB2 with a Ki of 1.44 nM. It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the 18F radiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.

Pharmacokinetics

AM-694 metabolism differs only slightly from that of JWH-018. AM-694 N-dealkylation produces fluoropentane instead of pentane (or plain alkanes in general). It has been speculated that the fluoropentane might function as an alkylating agent or is further metabolized into toxic fluoroacetic acid. This is not true since fluoroalkanes do not act as alkylating agents under normal conditions and uneven fluoroalkane chains metabolize into substantially less toxic fluoropropanoic acid.

References

AM-694 Wikipedia


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