Trisha Shetty

AM 630

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Legal status  CA: Schedule II
PubChem CID  4302963
ChemSpider  3508738
Molar mass  504.36 g/mol
CAS Number  164178-33-0
IUPHAR/BPS  750
ChEMBL  CHEMBL181633
AM-630 httpsuploadwikimediaorgwikipediacommonsthu

AM-630 (6-Iodopravadoline) is a drug that acts as a potent and selective inverse agonist for the cannabinoid receptor CB2, with a Ki of 32.1 nM at CB2 and 165x selectivity over CB1, at which it acted as a weak partial agonist. It is used in the study of CB2 mediated responses and has been used to investigate the possible role of CB2 receptors in the brain. AM-630 is significant as one of the first indole derived cannabinoid ligands substituted on the 6-position of the indole ring, a position that has subsequently been found to be important in determining affinity and efficacy at both the CB1 and CB2 receptors, and has led to the development of a large number of related derivatives.

References

AM-630 Wikipedia


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