Entrez 85365 | Ensembl ENSG00000119523 | |
Aliases ALG2, CDGIi, NET38, hALPG2, CMS14, CMSTA3, alpha-1,3/1,6-mannosyltransferase External IDs MGI: 1914731 HomoloGene: 5930 GeneCards: ALG2 | ||
Alpha-1,3-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation
Contents
Function
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).
Interactions
ALG2 has been shown to interact with ANXA7 and ANXA11.
References
ALG2 Wikipedia(Text) CC BY-SA