Girish Mahajan

AKTIP

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Species  Human
Entrez  64400
Human  Mouse
Ensembl  ENSG00000166971
AKTIP
Aliases  AKTIP, FT1, FTS, AKT interacting protein
External IDs  MGI: 3693832 HomoloGene: 7721 GeneCards: AKTIP

AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.

Contents

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Interactions

AKTIP has been shown to interact with AKT1.

Molecular genetics

The association between the AKTIP gene variants in a sample of 273 bipolar patients using 3 single-nucleotide polymorphisms has been investigated. No association between suicidal behavior and AKTIP variants nor any interaction between AKTIP and AKT1 polymorphisms was observed.

References

AKTIP Wikipedia


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