Samiksha Jaiswal

AKAP8

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Species  Human
Entrez  10270
Human  Mouse
Ensembl  ENSG00000105127
AKAP8
Aliases  AKAP8, AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
External IDs  MGI: 1928488 HomoloGene: 4278 GeneCards: AKAP8

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

Contents

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA.

Interactions

AKAP8 has been demonstrated to interact with:

  • Cyclin D3
  • DDX5,
  • MCM2,
  • MYCBP, and
  • PRKAR2A.
  • References

    AKAP8 Wikipedia


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