Puneet Varma

AKAP11

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Species  Human
Entrez  11215
Human  Mouse
Ensembl  ENSG00000023516
AKAP11
Aliases  AKAP11, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs  MGI: 2684060 HomoloGene: 8279 GeneCards: AKAP11

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.

Contents

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.

Interactions

AKAP11 has been shown to interact with:

  • GSK3B,
  • PPP1CA,
  • PRKAR2A, and
  • PRKAR2B.
  • References

    AKAP11 Wikipedia


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