Species Human Entrez 8728 | Human Mouse Ensembl ENSG00000135074 | |
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Aliases ADAM19, MADDAM, MLTNB, FKSG34, ADAM metallopeptidase domain 19 External IDs MGI: 105377 HomoloGene: 74925 GeneCards: ADAM19 | ||
ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.
Contents
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.
Interactions
ADAM19 has been shown to interact with ABI2.